Axcelead will offer a comprehensive set of best-in-class capabilities to meet a range of customer needs.

Research consulting

Over 200 highly qualified discovery scientists, headed by industry leaders with ~30 years’ experience:

  • Chair of R&D Committee of JPMA1
  • Board member of Kanagawa R&D Committee
  • Board of Directors of Japan Bio-industry Association
  • Board of Directors of The Research Foundation for Pharmaceutical Sciences
  • Board of Directors of the Japanese Society of Toxicology
  • Grand Review Committee of AMED
  • Several ICH working team members
  • Editorial board member of Medicinal Chemistry
    Communications, Journal of Toxicologic Pathology
  • Foundation member of JBF2


  • In vitro/in vivo pharmacology for multiple TAs
  • Molecular biology
  • Multi-omics analysis using gene-edited cells/animals, patient samples and clinical  information
  • Bioinformatics
  • Proprietary animal models, such as transgenic, knock out, humanized and immunodeficiency



  • High-quality and diversified compound library of ~1.0 million compounds
  • Compound library logistics (fully automated, state-of-the-art robotics)
  • High throughput screening (~300,000 compounds/day) for multiple target classes with track record of more than 500 campaign
  • In vitro assay (profiling) for Hit to Lead/Lead Generation/Lead Optimization
  • Protein science and Bio-physical analysis



  • High throughput ADME screening
  • In vitro/ in vivo DMPK studies for project start to IND (rodents and non-rodents)
  • PK/PD analysis, modelling and simulations
  • Human PK analysis and prediction
  • Non-clinical / clinical bioanalysis and metabolite ID identification for multiple modalities
  • Physical chemical profiling and solid form screening
  • Pre-formulation studies



  • Medicinal chemistry (Hit Identification, Lead Generation, Lead Optimization)
  • Design and synthesis of novel compounds for multiple target classes (Kinase, Enzyme, GPCR, Ion Channel, PPI, etc. ) and multiple molecular classes (Small molecule, Macrocycle, Peptide, Nucleic acid)
  • Peptide chemistry
  • Computational chemistry (SBDD / LBDD / FBDD / Binding mode prediction / Dynamics simulation / Automated design / in silico screening / Library design)
  • Cheminformatics
  • High-throughput parallel synthesis
  • Synthetic route design and Scale-up synthesis
  • Labelled compound synthesis
  • Analytical chemistry (X-ray, NMR, HPLC)


  • Predictive toxicology
  • GLP toxicology for IND
  • Investigative toxicology
  • Tumorgenic assessment of cell-therapy products
  • Safety pharmacology
  • Rodents and non-rodents studies available for both toxicology and safety pharmacology


Animal care (collaboration with Takeda Rabbics)

  • AAALAC and GLP Accredited Animal Care & Use program
  • Veterinary service
  • (Animal breeding)